Avandia Linked to Increased Risk of Heart Attack and Death
Avandia, a widely prescribed drug to treat type 2 diabetes, has been shown to increase users' risk of heart attack by 43 percent and cardiac-related death by 64 percent, according to researchers.
Because of the public health importance of this study, the New England Journal of Medicine released an early online version of an article that will appear in its June 14 issue.
More than 6 million people worldwide have used Avandia (generic name rosiglitazone) since it was approved 8 years ago to help control blood sugar in people with type 2 diabetes, the most common form of diabetes Currently, about 1 million Americans use Avandia.
The recent study was conducted by two doctors at the Cleveland Clinic who evaluated 42 studies that compared patients taking Avandia with those who were not. The overall study involved 28,000 patients, 15,560 of whom were taking Avandia.
Of those patients taking Avandia, 86 suffered heart attacks compared to 72 among patients not on the drug. In addition, another 39 patients died from cardiovascular causes compared to 22 patients who were not taking Avandia.
The Food and Drug Administration issued a safety alert on May 21, 2007 and will likely convene an advisory panel to look into the safety of Avandia.
Avandia is manufactured by GlaxoSmithKline, PLC.